Vincenza Andrisano Selected Research

AP 2238

4/2014	From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease.
3/2010	Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
6/2003	3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.

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Vincenza Andrisano Research Topics

Disease

63	Alzheimer Disease (Alzheimer's Disease) 09/2022 - 02/2003
6	Neoplasms (Cancer) 09/2022 - 10/2010
2	Dementia (Dementias) 09/2022 - 05/2011
2	Neuroblastoma 09/2022 - 01/2016
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2016
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 02/2013 - 01/2012
2	Colonic Neoplasms (Colon Cancer) 10/2012 - 12/2009
1	Pain (Aches) 09/2022
1	Ovarian Epithelial Carcinoma 09/2020
1	Neoplasm Metastasis (Metastasis) 09/2020
1	Ovarian Neoplasms (Ovarian Cancer) 09/2020
1	Disease Progression 01/2018
1	Astrocytoma (Pilocytic Astrocytoma) 12/2017
1	Tics (Tic) 03/2014
1	Heroin Dependence (Heroin Abuse) 07/2013
1	Proteostasis Deficiencies 02/2013
1	AIDS-Related Complex (ARC) 09/2009
1	Amyloid Plaque 07/2007
1	Type 2 Diabetes Mellitus (MODY) 10/2006
1	Necrosis 05/2005

Drug/Important Bio-Agent (IBA)

14	Pharmaceutical PreparationsIBA 09/2022 - 11/2007
14	LigandsIBA 01/2021 - 12/2004
9	Amyloid (Amyloid Fibrils)IBA 09/2022 - 05/2011
9	Biological ProductsIBA 01/2020 - 01/2005
9	EnzymesIBA 12/2014 - 02/2003
8	Peptides (Polypeptides)IBA 09/2022 - 07/2007
8	Tacrine (Cognex)FDA Link 01/2017 - 02/2003
7	Amyloid beta-PeptidesIBA 11/2012 - 06/2003
6	Cholinesterase Inhibitors (Anticholinesterases)IBA 03/2016 - 11/2005
6	AcetylcholinesteraseIBA 01/2016 - 06/2003
5	memoquinIBA 12/2011 - 11/2007
4	Cholinesterases (Cholinesterase)IBA 01/2021 - 06/2012
4	PolyaminesIBA 12/2016 - 03/2003
3	AlkaloidsIBA 01/2020 - 03/2016
3	ButyrylcholinesteraseIBA 01/2018 - 03/2009
3	CarbamatesIBA 12/2017 - 11/2004
3	AP 2238IBA 04/2014 - 06/2003
3	Proteins (Proteins, Gene)FDA Link 06/2011 - 08/2008
3	quinone (benzoquinone)IBA 09/2009 - 10/2007
2	Biomarkers (Surrogate Marker)IBA 09/2022 - 01/2017
2	Monoamine Oxidase (MAO)IBA 01/2021 - 06/2012
2	GoldIBA 01/2021 - 08/2008
2	Glycogen Synthase KinasesIBA 01/2021 - 01/2021
2	Cholinergic Agents (Cholinergics)IBA 01/2017 - 06/2005
2	Immobilized EnzymesIBA 03/2016 - 03/2009
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 05/2005
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2014 - 06/2011
1	LipidsIBA 09/2022
1	Fentanyl (Sublimaze)FDA LinkGeneric 09/2022
1	Plant ExtractsIBA 05/2022
1	Neuroprotective AgentsIBA 05/2022
1	Calcium Channels (Calcium Channel)IBA 01/2021
1	indoleIBA 09/2020
1	Hormones (Hormone)IBA 09/2020
1	Estrogen Receptor betaIBA 09/2020
1	Cytostatic AgentsIBA 09/2020
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 09/2020
1	QuinazolinesIBA 09/2020
1	hemanthamineIBA 01/2020
1	EstersIBA 01/2020
1	isoquinolineIBA 01/2019
1	Glycogen Synthase Kinase 3IBA 09/2017
1	Phosphotransferases (Kinase)IBA 09/2017
1	uleineIBA 01/2017
1	AntioxidantsIBA 03/2016
1	cardanolIBA 01/2016
1	benzofuranIBA 01/2016
1	EndocannabinoidsIBA 01/2016
1	Oxyquinoline (8 Hydroxyquinoline)FDA Link 01/2016
1	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 01/2016
1	coumarinIBA 01/2016
1	benzophenoneIBA 05/2014
1	rheinIBA 03/2014
1	SteroidsIBA 03/2014
1	formic acid (formate)IBA 03/2014
1	acetonitrileIBA 03/2014
1	QuinonesIBA 12/2013
1	Illicit Drugs (Recreational Drugs)IBA 07/2013
1	styrylquinolineIBA 02/2013
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2013
1	Adenosine Triphosphate (ATP)IBA 01/2013
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2013
1	AcidsIBA 10/2012
1	9-hydroxystearic acidIBA 10/2012
1	Oxidoreductases (Dehydrogenase)IBA 06/2012
1	AminesIBA 06/2012
1	Thioctic Acid (Lipoic Acid)IBA 11/2011
1	lipocrineIBA 11/2011
1	Protein Isoforms (Isoforms)IBA 10/2010
1	indacrinoneIBA 03/2010
1	entinostat (MS 275)IBA 12/2009
1	Vorinostat FDA Link 12/2009
1	Histone Deacetylase InhibitorsIBA 12/2009
1	MC1568IBA 12/2009
1	Histones (Histone)IBA 12/2009
1	XenonIBA 09/2009
1	1,4-dihydropyridine (dihydropyridine)IBA 05/2009
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 08/2008

Therapy/Procedure

9	Therapeutics 09/2020 - 03/2003
1	Traditional Medicine (Folk Remedies) 03/2016